From THE DIVISION OF NEUROLOGY DEPARTMENT OF CLINICAL NEUROSCIENCE Karolinska Institutet, Stockholm, Sweden GENETIC VARIATIONS INFLUENCING SUSCEPTIBILITY TO MULTIPLE SCLEROSIS
نویسنده
چکیده
Multiple sclerosis (MS) is a chronic neurological disease affecting approximately 12 000 individuals in Sweden. Epidemiological studies have shown that most likely several genetic variations contribute and interact with each other as well as with environmental factors in the development of MS. The disease is characterized by focal infiltration of inflammatory cells in the brain and spinal cord, demyelination of axons as well as neurodegeneration. In this thesis we examined the risk of MS in relation to genetic variations in selected candidate genes and gene expression induced by neurodegeneration in an experimental animal model
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تاریخ انتشار 2005